Metformin (brand name: Glucophage) is an oral anti-diabetic medicine meant specifically for Type 2 Diabetics. It has become the most commonly prescribed oral medication for the treatment of diabetes. Metformin is often the first line of drug therapy for many people diagnosed with type 2 diabetes. Metformin, also sold under the trade name Glucophage, was the wonder drug of the early 1990’s for type 2 diabetics.
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How Metformin works
Metformin belongs to biguanide class of anti diabetic drugs which is originated from French lilac (Galega officinals) plant used in folk medicine.
Glucophage helps to control the amount of glucose (sugar) in your blood. It does this in three main ways:
1. It decreases the amount of glucose you absorb from the food you eat
2. It decreases the amount of glucose made by your liver.
3. Also helps your body to respond better to insulin natural or injected.
Glucophage (cheap Metformin online) helps reduce plasma glucose levels and lowers the production of glucose by the liver, without increasing the concentration of insulin in the blood. This unique effect on blood insulin level is what separates Glucophage from other glucose-lowering drugs of the sulfonylurea class, e.g. glyburide (Micronase; Diabeta) or glipizide (Glucotrol).
Unlike other most commonly prescribed oral diabetic drugs such as glyburide or glipizide, Metformin does not increase the insulin concentration in blood and does not leads to low sugar levels (hypoglycaemia) when taken alone.
Metformin online is an effective treatment for diabetes. Since it acts at the source of the problem it helps to fight insulin resistance and also prevents and delays the onset of type 2 diabetes which leads to impaired glucose tolerance and insulin resistance. Glucophage - cheap Metformin online also helps to reduce risk of diabetes-related death, heart attacks and strokes various other diseases.
What you need to know about Metformin
Scientific studies had been conducted to prove that Glucophage reduces the complications of diabetes such as heart and kidney diseases, as well as blindness. It’s been successful in lowering blood sugar levels without going about it excessively.
Here is additional information for using Glucophage for it’s maximum effect:
- The effects are greatest 2 to 3 hours after you take medication. If you eat more carbohydrate at some meals than others, it makes sense to take your diabetic drug just before your most carb-heavy meal of the day.
- The same amount of Glucophage at the same time every day. If you forget a dose, don’t double up. This can cause your blood sugar levels to run too low.
- Taking Metformin at night can be helpful if you experience the dawn phenomenon, which is unusually high blood sugar levels due to a stress reaction in the hour or two before you wake up. Your kidneys will clear the drug out of your system at night, however, and you will be more likely to need to get up to pass urine.
- The effects of this medication on your blood sugar levels build up over the course of about a week. If you stop Glucophage, it will be about a week before your blood sugar levels spike upward.
- Glucophage may help with weight loss. Actos (pioglitazone) and Avandia (rosiglitazone) also increase insulin sensitivity, but at the cost of activating a gene that encourages the development of new fat cells. Metformin helps type 2 diabetics lower blood sugar levels by making cells more sensitive to insulin, and when less insulin is needed to transport sugar, less insulin is available to transport fat.
The advantages of Metformin
The advantages are that it has a much short action time and has a much lower risk for severe side effects and is quite safe for use by anyone who is otherwise healthy. In fact, in the major UKPDS study, it was the only drug that reduced diabetes-related death rates, heart attacks, and strokes.
Metformin lowers fasting blood glucose levels by an average of 25%, postprandial blood glucose up to 44.5%, and the HbA1c by an average of 1.5%. Metformin reduces raised plasma insulin levels in cases of metabolic syndrome by as much as 30% and reduces the need for injected insulin in Type 2s by 15 to 32%.
The 10 year UKPDS Study of over 3,000 people with Type 2 diabetes found that those who were placed on Glucophage had a 36% decrease in overall mortality and a 39% decrease in heart attacks.
Previous laboratory and public health studies have suggested that Glucophage may also be able to suppress cancer cell proliferation, and to reduce the risk of death due to cancer. However, thus far, there has been very little direct clinical research evidence available to support this hypothesis.
Precaution when using Metformin
Only your doctor can tell you how much Metformin and how many times a day you need. Do not take more or less of it than what your doctor has prescribed. The diabetic drug controls diabetes but does not cure it. Continue to take Glucophage even if you feel well. Do not stop Metformin without talking to your doctor.
If you have a history of heart, liver of kidney disease, do not take this drug.
Side effects such as:
* loss of appetite
* nausea
* stomach upset
* diarrhea
Other side effects might include symptoms of an allergic reaction such as throat, tongue, lip, or face swelling, breathing problems, or hives. You might also experience shortness of breath, even with the mildest of exertion, rapid weight gain, swelling, flu-like symptoms, body aches, chills, fever, headache, weakness, or even mild nausea. While taking Metformin, you might experience stomach pain, gas, diarrhea, vomiting, or muscle pain as well.
These may occur during the first few weeks of taking the medication but are seldom long-lasting. Taking Glucophage with food and starting out with a low dose help reduce side effects. The dosage can be gradually increased as side effects diminish.
If you need more information about cheap Metformin online (Glucophage), I urge you to talk to your doctor or a qualified professional how to buy Metformin online.
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